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Lidocaine suppresses HER2-positive breast cancer cell proliferation by targeting the OGT-CCNL1 axis

Abstract Background HER2-positive breast cancer, known for its heterogeneity and complex molecular mechanisms, poses a significant therapeutic challenge. Lidocaine, a widely used local anesthetic, has recently been identified as a potential anticancer agent. This study investigates the effects of li...

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Principais autores: Yunfei Sun, Bo Liu, Xuan Zhang, Chengqi Deng, Nan Hu, Yiqing Yin
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer 2025-12-01
סדרה:Discover Oncology
נושאים:
Lidocaine
HER2-positive breast cancer
O-GlcNAcylation
OGT
CCNL1
Proliferation
גישה מקוונת:https://doi.org/10.1007/s12672-025-04194-4
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