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De novo and long-term l-Dopa induce both common and distinct striatal gene profiles in the hemiparkinsonian rat

We compared for the first time the effects of de novo versus long-term l-Dopa treatment inducing abnormal involuntary movement on striatal gene profiles and related bio-associations in the 6-hydroxydopamine rat model of Parkinson's disease. We examined the pattern of striatal messenger RNA expressio...

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Principais autores: Michèle El Atifi-Borel, Virginie Buggia-Prevot, Nadine Platet, Alim-Louis Benabid, François Berger, Véronique Sgambato-Faure
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2009-05-01
Serier:Neurobiology of Disease
Fag:
Parkinson's disease
6-hydroxydopamine
Dyskinesia
Transcriptome
Microarray
Striatum
Online adgang:http://www.sciencedirect.com/science/article/pii/S096999610900031X
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