Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease

Prolonged l-3,4-dihydroxyphenylalanine (l-DOPA) administration, the gold standard therapy for Parkinson's disease (PD) is associated with serious motor complications, known as l-DOPA-induced dyskinesia (LID). One of the major molecular changes associated with LID is the increased activity of the ext...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Chiara Fiorentini, Paola Savoia, Daria Savoldi, Alessandro Barbon, Cristina Missale
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2013-06-01
coleção:	Neurobiology of Disease
Assuntos:	Parkinson's disease l-DOPA-induced dyskinesia Caudate-putamen Dopamine D1 receptors Shp-2
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996113000296
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!