Isoorientin Ameliorates APAP-Induced Hepatotoxicity via Activation Nrf2 Antioxidative Pathway: The Involvement of AMPK/Akt/GSK3β

Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been shown to have antioxidant potential. However, the effect of Iso on APAP-induced liver injury has not yet been elucidated. Th...

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Principais autores:	Xiaoye Fan, Hongming Lv, Lidong Wang, Xuming Deng, Xinxin Ci
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-11-01
Colecção:	Frontiers in Pharmacology
Assuntos:	acetaminophen APAP hepatotoxicity Isoorientin Iso Nrf2 oxidative stress
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphar.2018.01334/full
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