Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway

Abstract Background Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a key antioxidant transcription factor, is essential for alleviating APAP-induced hepatotoxicity. Corilagin (...

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Principais autores:	Hongming Lv, Lihua Hong, Ye Tian, Changjiu Yin, Chao Zhu, Haihua Feng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-01-01
coleção:	Cell Communication and Signaling
Assuntos:	Corilagin Acetaminophen Acute liver failure Oxidative stress Nrf2 AMPK/GSK3β
Acesso em linha:	http://link.springer.com/article/10.1186/s12964-018-0314-2
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