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Spatiotemporal development of the neuronal accumulation of amyloid precursor protein and the amyloid plaque formation in the brain of 3xTg-AD mice

The amyloid plaque is a hallmark of Alzheimer's disease. The accumulation of the amyloid precursor protein (APP) in the neuronal structure is assumed to lead to amyloid plaque formation through the excessive production of β-amyloid protein. To study the relationship between the neuronal accumulation...

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Principais autores: Munenori Ono, Tetsufumi Ito, Sachiko Yamaki, Yoshie Hori, Qing Zhou, Xirun Zhao, Shinji Muramoto, Ryo Yamamoto, Takafumi Furuyama, Hiromi Sakata-Haga, Toshihisa Hatta, Tsuyoshi Hamaguchi, Nobuo Kato
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-04-01
Serier:Heliyon
Fag:
Alzheimer's disease
Amyloid precursor protein
β-amyloid
Immunohistochemistry
Transgenic animal
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844024048527
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