Spatiotemporal development of the neuronal accumulation of amyloid precursor protein and the amyloid plaque formation in the brain of 3xTg-AD mice

The amyloid plaque is a hallmark of Alzheimer's disease. The accumulation of the amyloid precursor protein (APP) in the neuronal structure is assumed to lead to amyloid plaque formation through the excessive production of β-amyloid protein. To study the relationship between the neuronal accumulation...

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Detalhes bibliográficos

Principais autores:	Munenori Ono, Tetsufumi Ito, Sachiko Yamaki, Yoshie Hori, Qing Zhou, Xirun Zhao, Shinji Muramoto, Ryo Yamamoto, Takafumi Furuyama, Hiromi Sakata-Haga, Toshihisa Hatta, Tsuyoshi Hamaguchi, Nobuo Kato
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-04-01
Colecção:	Heliyon
Assuntos:	Alzheimer's disease Amyloid precursor protein β-amyloid Immunohistochemistry Transgenic animal
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2405844024048527
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