Autoinflammation with infantile enterocolitis induced by a heterozygous variant (c.1357C > T) in the NLRC4 gene: a case report

BackgroundNecrotizing enterocolitis (NEC) is s a life-threatening inflammatory intestinal disorder primarily affecting preterm infants, though rare in full-term neonates. NLR-family CARD domain-containing protein 4 (NLRC4), a cytosolic inflammasome component driving IL-1β-mediated inflammation, is l...

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Ngā kaituhi matua:	Xing Wang, Yongmei Xiao, Ting Ge, Ting Zhang, Xiaolu Li
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2026-05-01
Rangatū:	Frontiers in Pediatrics
Ngā marau:	enterocolitis autoinflammatory diseases gain-of-function infant necrotizing enterocolitis NLRC4 protein human mutation
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fped.2026.1822554/full
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