The Partitioning of Newly Assimilated Linoleic and α-Linolenic Acids Between Synthesis of Longer-Chain Polyunsaturated Fatty Acids and Hydroxyoctadecaenoic Acids Is a Putative Branch Point in T-Cell Essential Fatty Acid Metabolism

Longer-chain polyunsaturated fatty acids (LCPUFAs) ≥20 carbons long are required for leukocyte function. These can be obtained from the diet, but there is some evidence that leukocytes can convert essential fatty acids (EFAs) into LCPUFAs. We used stable isotope tracers to investigate LCPUFA biosynt...

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Autors principals:	Johanna von Gerichten, Annette L. West, Nicola A. Irvine, Elizabeth A. Miles, Philip C. Calder, Karen A. Lillycrop, Barbara A. Fielding, Graham C. Burdge
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-10-01
Col·lecció:	Frontiers in Immunology
Matèries:	T lymphocyte oxylipin omega-3 and omega-6 polyunsaturated fatty acids desaturase elongase stable isotope
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.740749/full
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