In vitro and in silico analysis for elucidation of α-amylase and α-glucosidase: Synthesis, structural confirmation and drug likeness of benzothiazole derived thiazole base bis-Schiff base derivatives

In this study, we have synthesized S-substituted benzothiazole derived thiazole bearing bis-Schiff base derivatives (1–19) and characterized via different spectroscopic techniques including NMR and HR-EIMS and then screened against α-amylase and α-glycosidase. All the analogues show excellent inhibi...

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Principais autores:	Shoaib Khan, Tayyiaba Iqbal, Mujaddad Ur Rehman, Rafaqat Hussain, Yousaf Khan, Hayat Ullah, Mohsin Ali, Amjad Hussain, Saleh Alfarraj, Sulaiman Ali Alharbi
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2024-06-01
Series:	Results in Chemistry
Assuntos:	Diabetes Mellitus Benzothiazole Bis-Schiff base SAR Docking study and ADME
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S221171562400290X
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