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In vitro and in silico analysis for elucidation of α-amylase and α-glucosidase: Synthesis, structural confirmation and drug likeness of benzothiazole derived thiazole base bis-Schiff base derivatives

In this study, we have synthesized S-substituted benzothiazole derived thiazole bearing bis-Schiff base derivatives (1–19) and characterized via different spectroscopic techniques including NMR and HR-EIMS and then screened against α-amylase and α-glycosidase. All the analogues show excellent inhibi...

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Uloženo v:
Hlavní autoři: Shoaib Khan, Tayyiaba Iqbal, Mujaddad Ur Rehman, Rafaqat Hussain, Yousaf Khan, Hayat Ullah, Mohsin Ali, Amjad Hussain, Saleh Alfarraj, Sulaiman Ali Alharbi
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2024-06-01
Edice:Results in Chemistry
Témata:
Diabetes Mellitus
Benzothiazole
Bis-Schiff base
SAR
Docking study and ADME
On-line přístup:http://www.sciencedirect.com/science/article/pii/S221171562400290X
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