Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution

Abstract Double-strand breaks (DSBs) result from the attack of both DNA strands by multiple sources, including radiation and chemicals. DSBs can cause the abnormal chromosomal rearrangements associated with cancer. Recent techniques allow the genome-wide mapping of DSBs at high resolution, enabling...

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Detalles Bibliográficos

Autores principales:	Raphaël Mourad, Krzysztof Ginalski, Gaëlle Legube, Olivier Cuvier
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2018-03-01
Colección:	Genome Biology
Materias:	Double-strand breaks Epigenetics Chromatin Machine learning
Acceso en línea:	http://link.springer.com/article/10.1186/s13059-018-1411-7
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