Integrative Sequencing and Proteogenomic Approaches to Intratumoral Heterogeneity in Cholangiocarcinoma: Implications for Precision Diagnosis and Therapy

Cholangiocarcinoma (CCA) is a highly aggressive cancer of the biliary tract, distinguished by significant intratumoral heterogeneity (ITH), which contributes to therapy resistance and unfavorable clinical outcomes. Traditional genome profiling has revealed recurring driver changes in CCA; yet, genom...

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Main Authors:	Sirinya Sitthirak, Arporn Wangwiwatsin, Apinya Jusakul, Nisana Namwat, Poramate Klanrit, Sittiruk Roytrakul, Hasaya Dokduang, Thitinat Duangchan, Yanisa Rattanapan, Attapol Titapun, Apiwat Jareanrat, Vasin Thanasukarn, Natcha Khuntikeo, Teh Bin Tean, Luke Boulter, Yoshinori Murakami, Watcharin Loilome
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2026-01-01
Series:	Medical Sciences
Subjects:	cholangiocarcinoma clonal evolution intratumoral heterogeneity mass spectrometry multi-omics proteogenomics
Online Access:	https://www.mdpi.com/2076-3271/14/1/30
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