Whole exome sequencing of multi-regions reveals tumor heterogeneity in Opisthorchis viverrini-associated cholangiocarcinoma

Abstract The study examines Opisthorchis viverrini (OV)-related cholangiocarcinoma (CCA), a serious malignancy common in Southeast Asia. Through multi-regional whole-exome sequencing of 52 tumor samples and 13 adjacent tissues from 13 patients, significant intratumoral heterogeneity (ITH) and inter-...

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Autores principales:	Sirinya Sitthirak, Arporn Wangwiwatsin, Apinya Jusakul, Nisana Namwat, Poramate Klanrit, Hasaya Dokduang, Prakasit Sa-ngiamwibool, Attapol Titapun, Apiwat Jareanrat, Vasin Thanasukarn, Natcha Khuntikeo, Bin Tean Teh, Luke Boulter, Yoshinori Murakami, Watcharin Loilome
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-03-01
Colección:	Scientific Reports
Materias:	Cholangiocarcinoma Multi-region sequencing Tumor heterogeneity Clonal evolution Phylogenetic tree
Acceso en línea:	https://doi.org/10.1038/s41598-025-95142-3
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