Targeting QKI-7 in vivo restores endothelial cell function in diabetes

Abstract Vascular endothelial cell (EC) dysfunction plays a key role in diabetic complications. This study discovers significant upregulation of Quaking-7 (QKI-7) in iPS cell-derived ECs when exposed to hyperglycemia, and in human iPS-ECs from diabetic patients. QKI-7 is also highly expressed in hum...

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Главные авторы:	Chunbo Yang, Magdalini Eleftheriadou, Sophia Kelaini, Thomas Morrison, Marta Vilà González, Rachel Caines, Nicola Edwards, Andrew Yacoub, Kevin Edgar, Arya Moez, Aleksandar Ivetic, Anna Zampetaki, Lingfang Zeng, Fiona L. Wilkinson, Noemi Lois, Alan W. Stitt, David J. Grieve, Andriana Margariti
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2020-07-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-020-17468-y
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