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In vivo Analysis of CRISPR/Cas9 Induced Atlastin Pathological Mutations in Drosophila

The endoplasmic reticulum (ER) is a highly dynamic network whose shape is thought to be actively regulated by membrane resident proteins. Mutation of several such morphology regulators cause the neurological disorder Hereditary Sp astic Paraplegia (HSP), suggesting a critical role of ER shape mainte...

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Principais autores: Aldo Montagna, Nicola Vajente, Diana Pendin, Andrea Daga
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2020-10-01
סדרה:Frontiers in Neuroscience
נושאים:
atlastin
mutation
CRISPR/Cas9
hereditary spastic paraplegia
endoplasmic reticulum
Golgi
גישה מקוונת:https://www.frontiersin.org/article/10.3389/fnins.2020.547746/full
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