In vivo Analysis of CRISPR/Cas9 Induced Atlastin Pathological Mutations in Drosophila

The endoplasmic reticulum (ER) is a highly dynamic network whose shape is thought to be actively regulated by membrane resident proteins. Mutation of several such morphology regulators cause the neurological disorder Hereditary Sp astic Paraplegia (HSP), suggesting a critical role of ER shape mainte...

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Autores principales:	Aldo Montagna, Nicola Vajente, Diana Pendin, Andrea Daga
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2020-10-01
Colección:	Frontiers in Neuroscience
Materias:	atlastin mutation CRISPR/Cas9 hereditary spastic paraplegia endoplasmic reticulum Golgi
Acceso en línea:	https://www.frontiersin.org/article/10.3389/fnins.2020.547746/full
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