Targeting autophagy in platinum-sensitive relapsed ovarian cancer: randomized phase II trial of hydroxychloroquine with chemotherapy with biomarker correlation

Abstract Background Autophagy activation contributes to chemotherapy resistance in several cancers, including ovarian cancer. Hydroxychloroquine (HCQ) is an autophagy inhibitor inhibiting the fusion of the autophagosome with the lysosome and has been repurposed as an anti-cancer agent. In this rando...

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Huvudupphov:	Luxitaa Goenka, Biswajit Dubashi, Smita Kayal, Medha Rajappa, Prabhu Manivannan, Sunitha Vellathussery Chakkalakkoombil, Debasis Gochhait, Latha Chaturvedula, S. Pradeep, Annuja Anandaradje, Alladi Charanraj Goud, Prasanth Ganesan
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Springer 2025-02-01
Serie:	Discover Oncology
Ämnen:	Platinum sensitive relapsed ovarian cancer Autophagy Hydroxychloroquine Biomarkers Toxicity
Länkar:	https://doi.org/10.1007/s12672-025-01904-w
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