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Targeting autophagy in platinum-sensitive relapsed ovarian cancer: randomized phase II trial of hydroxychloroquine with chemotherapy with biomarker correlation

Abstract Background Autophagy activation contributes to chemotherapy resistance in several cancers, including ovarian cancer. Hydroxychloroquine (HCQ) is an autophagy inhibitor inhibiting the fusion of the autophagosome with the lysosome and has been repurposed as an anti-cancer agent. In this rando...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Luxitaa Goenka, Biswajit Dubashi, Smita Kayal, Medha Rajappa, Prabhu Manivannan, Sunitha Vellathussery Chakkalakkoombil, Debasis Gochhait, Latha Chaturvedula, S. Pradeep, Annuja Anandaradje, Alladi Charanraj Goud, Prasanth Ganesan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer 2025-02-01
Schriftenreihe:Discover Oncology
Schlagworte:
Platinum sensitive relapsed ovarian cancer
Autophagy
Hydroxychloroquine
Biomarkers
Toxicity
Online-Zugang:https://doi.org/10.1007/s12672-025-01904-w
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