Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency

In the context of glucocorticoid (GC) therapeutics, recent studies have utilised a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver multiple HC pulses throughout the day, with the purpose of restoring normal circadian and ultradian GC rhythmicity. A key challenge for the advancem...

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Autori principali:	Ioannis G. Violaris, Konstantinos Kalafatakis, Eder Zavala, Ioannis G. Tsoulos, Theodoros Lampros, Stafford L. Lightman, Markos G. Tsipouras, Nikolaos Giannakeas, Alexandros Tzallas, Georgina M. Russell
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-05-01
Serie:	Pharmaceutics
Soggetti:	glucocorticoid pulsatility pharmacokinetic model subcutaneous delivery glucocorticoid insufficiency hydrocortisone replacement therapy
Accesso online:	https://www.mdpi.com/1999-4923/13/6/769
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