Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency

In the context of glucocorticoid (GC) therapeutics, recent studies have utilised a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver multiple HC pulses throughout the day, with the purpose of restoring normal circadian and ultradian GC rhythmicity. A key challenge for the advancem...

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Auteurs principaux:	Ioannis G. Violaris, Konstantinos Kalafatakis, Eder Zavala, Ioannis G. Tsoulos, Theodoros Lampros, Stafford L. Lightman, Markos G. Tsipouras, Nikolaos Giannakeas, Alexandros Tzallas, Georgina M. Russell
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2021-05-01
Collection:	Pharmaceutics
Sujets:	glucocorticoid pulsatility pharmacokinetic model subcutaneous delivery glucocorticoid insufficiency hydrocortisone replacement therapy
Accès en ligne:	https://www.mdpi.com/1999-4923/13/6/769
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