Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines

Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. Greensporone A-mediated inhibition of proliferation is found to be associated with t...

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Detalles Bibliográficos

Principais autores:	Kirti S. Prabhu, Kodappully S. Siveen, Shilpa Kuttikrishnan, Anh Jochebeth, Tayyiba A. Ali, Noor R. Elareer, Ahmad Iskandarani, Abdul Quaiyoom Khan, Maysaloun Merhi, Said Dermime, Tamam El-Elimat, Nicholas H. Oberlies, Feras Q. Alali, Martin Steinhoff, Shahab Uddin
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2019-03-01
Series:	Biomolecules
Assuntos:	AKT apoptosis cIAP greensporone A imatinib reactive oxygen species
Acceso en liña:	https://www.mdpi.com/2218-273X/9/4/126
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