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Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

Abstract In eukaryote cells, core components of chromatin, such as histones and DNA, are packaged in nucleus. Leakage of nuclear materials into cytosol will induce pathological effects. However, the underlying mechanisms remain elusive. Here, cytoplasmic localization of nuclear materials induced by...

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Principais autores: Zhen Wang, Ji Chen, Chuan Gao, Qiong Xiao, Xi‐Wei Wang, Shan‐Bo Tang, Qing‐Lan Li, Bo Zhong, Zhi‐Yin Song, Hong‐Bing Shu, Lian‐Yun Li, Min Wu
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2021-10-01
Serier:Advanced Science
Fag:
autophagy
cGAS
H3K9me3
heterochromatin
HP1α
SETDB1
Online adgang:https://doi.org/10.1002/advs.202100779
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