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SUV39H1-DNMT3A-mediated epigenetic regulation of Tim-3 and galectin-9 in the cervical cancer

Abstract Background Methylation of histone 3 at lysine 9 (H3K9) and DNA methylation are epigenetic marks correlated with genes silencing. The tumor microenvironment significantly influences therapeutic responses and clinical outcomes. The epigenetic-regulation mechanism of the costimulatory factors...

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Principais autores: Li Zhang, Sijuan Tian, Minyi Zhao, Ting Yang, Shimin Quan, Qing Yang, Lihua Song, Xiaofeng Yang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-07-01
coleção:Cancer Cell International
Assuntos:
Cervical cancer
SUV39H1
H3K9me3
DNMT3A
Tim-3
Galectin-9
Acesso em linha:http://link.springer.com/article/10.1186/s12935-020-01380-y
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