Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers

Abstract Expression or phosphorylation levels of leucine-rich repeat kinase 2 (LRRK2) and its Rab substrates have strong potential as disease or pharmacodynamic biomarkers. The main objective of this study is therefore to assess the LRRK2-Rab pathway for use as biomarkers in human, non-human primate...

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Hauptverfasser:	Jean-Marc Taymans, Eugénie Mutez, William Sibran, Laurine Vandewynckel, Claire Deldycke, Séverine Bleuse, Antoine Marchand, Alessia Sarchione, Coline Leghay, Alexandre Kreisler, Clémence Simonin, James Koprich, Guillaume Baille, Luc Defebvre, Kathy Dujardin, Alain Destée, Marie-Christine Chartier-Harlin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2023-02-01
Schriftenreihe:	npj Parkinson's Disease
Online-Zugang:	https://doi.org/10.1038/s41531-023-00445-9
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