LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway

Objective: Adaptive rewiring of cancer energy metabolism has received increasing attention. By binding with LDLs, LDLRs make most of the circulating cholesterol available for cells to utilize. However, it remains unclear how LDLR works in HCC development by affecting cholesterol metabolism. Methods:...

Повний опис

Бібліографічні деталі

Автори:	Ziye Chen, Lu Chen, Bo Sun, Dongming Liu, Yuchao He, Lisha Qi, Guangtao Li, Zhiqiang Han, Linlin Zhan, Su Zhang, Keyun Zhu, Yi Luo, Liwei Chen, Ning Zhang, Hua Guo
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Elsevier 2021-09-01
Серія:	Molecular Metabolism
Предмети:	LDLR HCC Simvastatin Cholesterol biosynthesis MEK/ERK pathway DHCR24
Онлайн доступ:	http://www.sciencedirect.com/science/article/pii/S2212877821000752
Теги:	Додати тег Немає тегів, Будьте першим, хто поставить тег для цього запису!