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Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit

ABSTRACT Human antibody-based immunity to influenza A virus is limited by antigenic drift resulting from amino acid substitutions in the hemagglutinin (HA) head domain. Glycan addition can cause large antigenic changes but is limited by fitness costs to viral replication. Here, we report that glycan...

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Principais autores: Meghan O. Altman, Matthew Angel, Ivan Košík, Nídia S. Trovão, Seth J. Zost, James S. Gibbs, Lorenzo Casalino, Rommie E. Amaro, Scott E. Hensley, Martha I. Nelson, Jonathan W. Yewdell
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019-04-01
Serier:mBio
Fag:
influenza
viral evolution
hemagglutinin
immune evasion
glycosylation
Online adgang:https://journals.asm.org/doi/10.1128/mBio.00204-19
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