Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit

ABSTRACT Human antibody-based immunity to influenza A virus is limited by antigenic drift resulting from amino acid substitutions in the hemagglutinin (HA) head domain. Glycan addition can cause large antigenic changes but is limited by fitness costs to viral replication. Here, we report that glycan...

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Bibliografische Detailangaben

Hauptverfasser:	Meghan O. Altman, Matthew Angel, Ivan Košík, Nídia S. Trovão, Seth J. Zost, James S. Gibbs, Lorenzo Casalino, Rommie E. Amaro, Scott E. Hensley, Martha I. Nelson, Jonathan W. Yewdell
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2019-04-01
Schriftenreihe:	mBio
Schlagworte:	influenza viral evolution hemagglutinin immune evasion glycosylation
Online-Zugang:	https://journals.asm.org/doi/10.1128/mBio.00204-19
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