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Perineural invasion is a prognostic factor in cholangiocarcinoma, regardless of anatomical location: A systematic review and meta-analysis

Background & Aims: Cholangiocarcinoma (CCA), a heterogeneous malignancy that includes intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA) subtypes, often exhibits perineural invasion (PNI). Despite PNI being associated with postoperative recurrence, evidence on its prognostic impact remains...

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Principais autores: Sefora Conti, Natalia S. Tissera, Florian Castet, Míriam Basagaña-Farrés, María Teresa Salcedo, Elizabeth Pando, Cristina Dopazo, Lorenzo Caritá, Anthony Turpin, Víctor Navarro Garcés, Guillermo Villacampa, Teresa Macarulla, Tian V. Tian
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-04-01
Serier:JHEP Reports
Fag:
cholangiocarcinoma
perineural invasion
anatomic location
prognostic factor
overall survival
disease-free survival
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589555926000418
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