Gallic acid alleviates visceral hyperalgesia following maternal separation in mice by inhibiting EphrinB2/EphB2 signaling mediated activation of neurons and glial cells

BackgroundEarly life stress (ELS) causes functional gastrointestinal issues linked to visceral hyperalgesia. Activation of spinal neurons and glial cells is key to the development and persistence of visceral hyperalgesia. Our previous research has shown that EphrinB2/EphB2 signaling in the spinal co...

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Principais autores:	Shu-fen Guo, Yu Wang, Han Zheng, Hong-qin Tu, Yu-qing Xi, Dan Li, Zheng-liang Ma, Wei Zhang, Jia-ping Ruan
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2025-11-01
סדרה:	Frontiers in Immunology
נושאים:	visceral hypersensitivity early life stress maternal separation ephrinB2/ephB2 NMDA gallic acid
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1698744/full
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