Synthesis and biological evaluation of 4-phenoxy-phenyl isoxazoles as novel acetyl-CoA carboxylase inhibitors

Acetyl-CoA carboxylase (ACC) is a crucial enzyme in fatty acid metabolism, which plays a major role in the occurrence and development of certain tumours. Herein, one potential ACC inhibitor (6a) was identified through high-throughput virtual screening (HTVS), and a series of 4-phenoxy-phenyl isoxazo...

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Hlavní autoři:	Xin Wu, Yongbo Yu, Tonghui Huang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2021-01-01
Edice:	Journal of Enzyme Inhibition and Medicinal Chemistry
Témata:	acetyl-coa carboxylase antitumor docking cell cycle apoptosis
On-line přístup:	http://dx.doi.org/10.1080/14756366.2021.1936514
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