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Discovery of New 1,4,6-Trisubstituted-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridines with Anti-Tumor Efficacy in Mouse Model of Breast Cancer

Purine analogues are important therapeutic tools due to their affinity to enzymes or receptors that are involved in critical biological processes. In this study, new 1,4,6-trisubstituted pyrazolo[3,4-<i>b</i>]pyridines were designed and synthesized, and their cytotoxic potential was been studied. Th...

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Auteurs principaux: Maria Georgiou, Nikolaos Lougiakis, Roxane Tenta, Katerina Gioti, Stavroula Baritaki, Lydia-Evangelia Gkaralea, Elisavet Deligianni, Panagiotis Marakos, Nicole Pouli, Dimitris Stellas
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2023-02-01
Collection:Pharmaceutics
Sujets:
purine analogues
pyrazolopyridine
antiproliferative activity
anticancer agent
in vivo
breast cancer
Accès en ligne:https://www.mdpi.com/1999-4923/15/3/787
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