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Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci

Abstract Background Single-variant associations with age-related macular degeneration (AMD), one of the most prevalent causes of irreversible vision loss worldwide, have been studied extensively. However, because of a lack of refinement of these associations, there remains considerable ambiguity reg...

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Principais autores: Chris M. Pappas, Moussa A. Zouache, Stacie Matthews, Caitlin D. Faust, Jill L. Hageman, Brandi L. Williams, Burt T. Richards, Gregory S. Hageman
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2021-09-01
coleção:Human Genomics
Assuntos:
Age-related macular degeneration
CFH-CFHR5
ARMS2/HTRA1
Haplotype
Diplotype
Genetic association study
Acesso em linha:https://doi.org/10.1186/s40246-021-00359-8
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