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High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3*B

Dysregulation of the complement alternative pathway (AP) is a major pathogenic mechanism in atypical hemolytic-uremic syndrome (aHUS). Genetic or acquired defects in factor H (FH), the main AP regulator, are major aHUS drivers that associate with a poor prognosis. FH activity has been suggested to b...

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Principais autores: Richard B. Pouw, Irene Gómez Delgado, Alberto López Lera, Santiago Rodríguez de Córdoba, Diana Wouters, Taco W. Kuijpers, Pilar Sánchez-Corral
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-04-01
coleção:Frontiers in Immunology
Assuntos:
complement
factor H
factor H-related protein 3
CFHR3 gene
atypical hemolytic-uremic syndrome
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.00848/full
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