Spatiotemporally reprogrammed L-arginine metabolic nanoregulator potentiates immunotherapy

L-arginine (L-Arg) deprivation in the tumor microenvironment (TME) drives effector T cell dysfunction and immunotherapy resistance. However, simply supplementing L-Arg can be counterproductive, as tumor cells and immunosuppressive myeloid cells act as dominant consumers, co-opting the nutrient to pr...

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Главные авторы:	Qian Cheng, Xiaolei Shi, Qushuhua Qin, Yuzhe Chen, Jiawei Wang, Lin Wang, Zheng Wang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	KeAi Communications Co., Ltd. 2026-09-01
Серии:	Bioactive Materials
Предметы:	L-arginine deprivation Tumor microenvironment (TME) Immunotherapy resistance Metabolic competition Nanoregulator
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2452199X26002173
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