Spatiotemporally reprogrammed L-arginine metabolic nanoregulator potentiates immunotherapy
L-arginine (L-Arg) deprivation in the tumor microenvironment (TME) drives effector T cell dysfunction and immunotherapy resistance. However, simply supplementing L-Arg can be counterproductive, as tumor cells and immunosuppressive myeloid cells act as dominant consumers, co-opting the nutrient to pr...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
KeAi Communications Co., Ltd.
2026-09-01
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| coleção: | Bioactive Materials |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2452199X26002173 |
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