Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer
Abstract To investigate how spatial constraints shape cancer metabolism, we devised the spatial Flux Balance Analysis (spFBA) framework for the enrichment of spatial transcriptomics data with relative estimates of metabolic fluxes. Applying spFBA to newly generated high-resolution datasets of paired...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Portfolio
2026-01-01
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| Col·lecció: | npj Systems Biology and Applications |
| Accés en línia: | https://doi.org/10.1038/s41540-026-00654-x |
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