Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer

Abstract To investigate how spatial constraints shape cancer metabolism, we devised the spatial Flux Balance Analysis (spFBA) framework for the enrichment of spatial transcriptomics data with relative estimates of metabolic fluxes. Applying spFBA to newly generated high-resolution datasets of paired...

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Detalhes bibliográficos

Principais autores:	Davide Maspero, Giovanni Marteletto, Francesco Lapi, Bruno G. Galuzzi, Irene Ruano, Ben Vandenbosch, Ke Yin, Sabine Tejpar, Alex Graudenzi, Holger Heyn, Anna Pascual-Reguant, Chiara Damiani
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-01-01
Colecção:	npj Systems Biology and Applications
Acesso em linha:	https://doi.org/10.1038/s41540-026-00654-x
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