Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells

Weibel-Palade bodies are endothelial secretory organelles that contain von Willebrand factor, P-selectin and CD63. Release of von Willebrand factor from Weibel-Palade bodies is crucial for platelet adhesion during primary hemostasis. Endosomal trafficking of proteins like CD63 to Weibel-Palade bodie...

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Manylion Llyfryddiaeth

Prif Awduron:	Ellie Karampini, Maaike Schillemans, Menno Hofman, Floris van Alphen, Martin de Boer, Taco W. Kuijpers, Maartje van den Biggelaar, Jan Voorberg, Ruben Bierings
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Ferrata Storti Foundation 2019-10-01
Cyfres:	Haematologica
Mynediad Ar-lein:	https://haematologica.org/article/view/9092
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