β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer’s disease

IntroductionThe study of the pathophysiology study of Alzheimer’s disease (AD) has been hampered by lack animal models that recapitulate the major AD pathologies, including extracellular -amyloid (A) deposition, intracellular aggregation of microtubule associated protein tau (MAPT), inflammation and...

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Hlavní autoři:	Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Jenna Libera, Zihan Wang, Alper Kilci, Matthew Jenkins, Alejandro Rondón Ortiz, Luke Dorrian, Jingjing Sun, Guangxin Sun, Sherif Rashad, Caroline Kornbrek, Sarah Anne Daley, Peter C. Dedon, Brian Nguyen, Weiming Xia, Takashi Saito, Takaomi C. Saido, Benjamin Wolozin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-03-01
Edice:	Frontiers in Neuroscience
Témata:	tauopathy neurodegeneration RNA binding proteins tau oligomers neuropathology RNA methylation
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnins.2024.1372297/full
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