Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to App NL−G−F knock-in Alzheimer mice

Abstract Background Alzheimer’s disease (AD) is an age-related disease characterized by altered cognition, neuroinflammation, and neurodegeneration against which there is presently no effective cure. Brain-derived neurotrophic factor (BDNF) is a key neurotrophin involved in the learning and memory p...

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Bibliografische Detailangaben

Hauptverfasser:	Simone Tambaro, Sumonto Mitra, Ruchi Gera, Bengt Linderoth, Lars U. Wahlberg, Taher Darreh-Shori, Homira Behbahani, Per Nilsson, Maria Eriksdotter
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-08-01
Schriftenreihe:	Alzheimer’s Research & Therapy
Schlagworte:	Encapsulated cell biodelivery (ECB) Brain-derived neurotrophic factor (BDNF) Alzheimer’s disease (AD) App NL−G−F knock-in mice Therapy Drug delivery
Online-Zugang:	https://doi.org/10.1186/s13195-023-01282-x
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