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Phillygenin Suppresses Glutamate Exocytosis in Rat Cerebrocortical Nerve Terminals (Synaptosomes) through the Inhibition of Ca<sub>v</sub>2.2 Calcium Channels

Glutamate is a major excitatory neurotransmitter that mediates neuronal damage in acute and chronic brain disorders. The effect and mechanism of phillygenin, a natural compound with neuroprotective potential, on glutamate release in isolated nerve terminals (synaptosomes) prepared from the rat cereb...

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Principais autores: Ming-Yi Lee, Tzu-Yu Lin, Ya-Ying Chang, Kuan-Ming Chiu, Su-Jane Wang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-02-01
coleção:Biomedicines
Assuntos:
phillygenin
glutamate exocytosis
voltage-dependent Ca<sup>2+</sup> channel
cerebral cortex
synaptosomes
Acesso em linha:https://www.mdpi.com/2227-9059/12/3/495
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