Phillygenin Suppresses Glutamate Exocytosis in Rat Cerebrocortical Nerve Terminals (Synaptosomes) through the Inhibition of Ca_v2.2 Calcium Channels

Glutamate is a major excitatory neurotransmitter that mediates neuronal damage in acute and chronic brain disorders. The effect and mechanism of phillygenin, a natural compound with neuroprotective potential, on glutamate release in isolated nerve terminals (synaptosomes) prepared from the rat cereb...

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Hauptverfasser:	Ming-Yi Lee, Tzu-Yu Lin, Ya-Ying Chang, Kuan-Ming Chiu, Su-Jane Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2024-02-01
Schriftenreihe:	Biomedicines
Schlagworte:	phillygenin glutamate exocytosis voltage-dependent Ca<sup>2+</sup> channel cerebral cortex synaptosomes
Online-Zugang:	https://www.mdpi.com/2227-9059/12/3/495
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