Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors

Abstract Patients affected by neurofibromatosis type 1 (NF1) frequently show muscle weakness with unknown etiology. Here we show that, in mice, Neurofibromin 1 (Nf1) is not required in muscle fibers, but specifically in early postnatal myogenic progenitors (MPs), where Nf1 loss led to cell cycle exi...

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主要な著者:	Xiaoyan Wei, Angelos Rigopoulos, Matthias Lienhard, Sophie Pöhle-Kronawitter, Georgios Kotsaris, Julia Franke, Nikolaus Berndt, Joy Orezimena Mejedo, Hao Wu, Stefan Börno, Bernd Timmermann, Arunima Murgai, Rainer Glauben, Sigmar Stricker
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2024-02-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/s41467-024-45618-z
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