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Unraveling the Impact of KRAS Accessory Proteins on Oncogenic Signaling Pathways

The oncogene KRAS drives tumor growth by activating pathways such as MAPK and PI3K-AKT in a constitutive manner. Although direct KRAS inhibitors exist, they are often limited in clinical use due to therapeutic resistance and toxicity. Therefore, alternative combinatorial therapeutic strategies are u...

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Principais autores: Vanshika Garg, Raphael N. H. M. Hofmann, Moazzam Saleem, Amin Mirzaiebadizi, Ghazaleh Sadat Hashemi, Tooba Hameed, Bahareh Jooyeh, Silke Pudewell, Mehrnaz Mehrabipour, Niloufar Mosaddeghzadeh, Roland P. Piekorz, Mohammad Reza Ahmadian
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-01-01
Serier:Cells
Fag:
accessory proteins
KRAS oncogene
adenocarcinoma
Galectin-3
PDE-delta
nucleophosmin
Online adgang:https://www.mdpi.com/2073-4409/15/2/190
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