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KCa3.1 inhibition-induced activation of the JNK/c-Jun signaling pathway enhances IL-10 expression in peripherally-induced regulatory T cells

The KCa3.1 inhibition up-regulates IL-10 expression in regulatory T (Treg) cells in the recovery phase of inflammatory bowel disease (IBD) model mice; however, the underlying signaling pathway remains unclear. We investigated the involvement of AP-1 (Fos/Jun) and NF-κB in the expression of IL-10 and...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Miki Matsui, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Susumu Ohya
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2022-01-01
Rangatū:Journal of Pharmacological Sciences
Ngā marau:
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S1347861321000931
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