Iron deficiency induces maturation-dependent loss of pancreatic β-cells

Abstract Pancreatic β-cells maintain glucose homeostasis by secreting insulin in response to rising blood glucose, a process fueled by mitochondrial ATP production. Iron, a core cofactor in the electron transport chain, is essential for this metabolic coupling. While the cytotoxic effects of iron ov...

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Détails bibliographiques

Auteurs principaux:	Annelore Van Mulders, Lien Willems, Sophie Coenen, Stephanie Bourgeois, Xiaoyan Yi, Yue Tong, Gunter Leuckx, Yves Heremans, Julie Pierreux, Laure Degroote, Toshiaki Sawatani, Chiara Vinci, Gamze Ates, Ann Massie, Françoise Carlotti, Eelco de Koning, Thomas Mandrup-Poulsen, Clara Zelinsky, Steven Goderis, Bart Ghesquière, Raphael Scharfmann, Miriam Cnop, Nico De Leu, Willem Staels
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2026-02-01
Collection:	Nature Communications
Accès en ligne:	https://doi.org/10.1038/s41467-026-69574-y
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