Comprehensive alpha, beta, and delta cell transcriptomics reveal an association of cellular aging with MHC class I upregulation

Objectives: This study aimed to evaluate the efficacy of a purification method developed for isolating alpha, beta, and delta cells from pancreatic islets of adult mice, extending its application to islets from newborn and aged mice. Furthermore, it sought to examine transcriptome dynamics in mouse...

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Detalhes bibliográficos

Principais autores:	W. Staels, C. Berthault, S. Bourgeois, V. Laville, C. Lourenço, N. De Leu, R. Scharfmann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-09-01
coleção:	Molecular Metabolism
Assuntos:	Pancreatic islet Alpha cell Beta cell Delta cell Maturation MHC class I
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2212877824001212
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