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Mitochondrial TXNRD3 confers drug resistance via redox-mediated mechanism and is a potential therapeutic target in vivo

Alterations in ROS metabolism and redox signaling are often observed in cancer cells and play a significant role in tumor development and drug resistance. However, the mechanisms by which redox alterations impact cellular sensitivity to anticancer drugs remain elusive. Here we have identified the mi...

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Main Authors: Xiaoxia Liu, Yanyu Zhang, Wenhua Lu, Yi Han, Jing Yang, Weiye Jiang, Xin You, Yao Luo, Shijun Wen, Yumin Hu, Peng Huang
Format: Artigo
Language:Inglês
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Drug resistance
Sorafenib
TXNRD3
Redox modulation
Mitochondria
Auranofin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308570
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