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LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis

Abstract Human telomerase assembly is a highly dynamic process. Using biochemical approaches, we find that LARP3 and LARP7/MePCE are involved in the early stage of human telomerase RNA (hTR) and that their binding to RNA is destabilized when the mature form is produced. LARP3 plays a negative role i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tsai-Ling Kao, Yu-Cheng Huang, Yi-Hsuan Chen, Peter Baumann, Chi-Kang Tseng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Portfolio 2024-07-01
Cyfres:Nature Communications
Mynediad Ar-lein:https://doi.org/10.1038/s41467-024-50422-w
Tagiau: Ychwanegu Tag
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